Depakote (Valproate) Information

The active ingredient in Depakote is:

• Valproic acid (Valproate sodium): 125 mg, 250 mg, or 500 mg per tablet (oral form)

Other inactive ingredients may include:

• Magnesium stearate
• Gelatin
• Silicon dioxide
• Sodium lauryl sulfate

Common side effects include:

• Drowsiness or dizziness
• Nausea or vomiting
• Weight gain
• Tremors or shaking
• Hair loss

Serious side effects requiring immediate medical attention:

• Severe allergic reactions (rash, swelling, difficulty breathing)
• Signs of liver problems (yellowing of the skin or eyes, dark urine, fatigue)
• Unusual bruising or bleeding
• Confusion or changes in mental status
• Severe abdominal pain

Depakote is typically taken orally, with or without food. The dosage is individualized depending on the condition being treated, your age, and response to the medication. It is important to follow your doctor's instructions on the dosage and timing.

Important considerations:

• Take Depakote as prescribed. Do not adjust the dose or frequency without consulting your doctor.
• It may take a few days or weeks to experience the full effect of the medication.
• If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose.

Depakote can interact with a variety of medications. Be sure to tell your doctor about all other medications you are currently taking, including over-the-counter medications and supplements.

Common interactions include:

• Other anticonvulsants: May affect how Depakote works and require dose adjustments.
• Anticoagulants (blood thinners): Increased risk of bleeding.
• Alcohol: May increase side effects such as drowsiness and dizziness.
• Antidepressants and antipsychotics: May increase the risk of drowsiness and confusion.

Depakote typically starts to work within a few days to a week of starting treatment. However, it may take several weeks for the full effect to be seen, particularly when used for mood stabilization or seizure control. It is important to continue taking the medication even if you do not immediately notice an improvement in symptoms.

If you experience any of the serious side effects listed above, such as signs of liver problems, confusion, or unusual bruising, contact your doctor immediately or seek emergency medical attention. It is essential to monitor for any significant changes in your health while taking Depakote.